The response of masonry structures to explosions can be hardly investigated relying only on numerical and analytical tools. Experimental tests are of paramount importance for improving the current understanding and validating existing models. However, experiments of masonry structures under blast loads are limited in the available literature (see [1]). Moreover, conducting large-scale experiments is constrained by the need for specialized testing areas with restricted access, safety concerns, and limited repeatability. In contrast, reduced-scale experiments ensure a high degree of repeatability, moderate cost, and reduced risks associated with safety. We present herein a novel experimental setup to study masonry structures based on recently derived scaling laws (see [2], [3]). This setup enables us to collect data and analyze in detail the fast dynamics of masonry structures under explosions. Our experimental setup offers a high degree of control and repeatability, particularly in terms of the detonation of exploding wires, the resultant blast waves and structural deformations. Our experiments serve the purpose of validating existing numerical works, and reveal the salient features of masonry structures under blast loads. The results from this experimental setup are intended to enhance and refine both existing and new computational models for structures subjected to blast loads.