This study investigates the dynamics of droplet transmission containing infectious viruses during close-range communication, particularly when an individual speaks loudly. Employing Computational Fluid Particle Dynamics (CFPD) techniques with URANS, we elaborately investigated the dispersion of these droplets and the ensuing risks of exposure. To simulate some scenarios, two computer simulated persons—one infected and one healthy—were positioned facing each other at a distance of 0.3, 0.7, and 1.1 meters, a range associated with heightened exposure risk in the simple room with a displacement ventilation system. To accurately assess the inhalation exposure to droplets generated by speaking, the detailed airway model was connected with the healthy computer simulated person. In our simulation, we specifically release 213 droplets, with sizes from 0.9µm to 850µm, from the oral opening surface at the peak exhalation flow of the speaking flow profile. A total of 4260 droplets are released within approximately 18 seconds. The diameter of droplets varies with time due to the evaporation. This comprehensive analysis allowed us to precisely quantify the rates at which these droplets are inhaled and deposited on the skin surfaces depending on the interpersonal distances. Our findings provide an understanding of the mechanisms underlying droplet dispersion and subsequent exposure risk in close communication scenarios. By evaluating these factors, this study significantly contributes to the ongoing assessment and comprehension of potential infection risks during interpersonal interactions at close contact.