Adaptive civil structures can modify the response to external actions through sensing and actuation. This enables satisfying safety and serviceability criteria with much less material and carbon requirements than conventional design practices [1], [2], especially for stiffness-governed configurations e.g., high-rise and slender buildings, long-span bridges. The implementation of adaptive systems for large-scale configurations presents several challenges. Typically, large control forces and high power density are required. In addition, innovative connection details for the efficient integration of active components with structural elements such as slabs and columns need to be developed [3]. As high-rise design continues to push height and slenderness limits, the need for innovative and efficient structural systems becomes increasingly important. Exoskeleton systems have emerged as an effective solution to enable more flexible use of space, providing high structural performance thanks to the high stiffness-to-weight ratio. This work investigates the use of exoskeleton systems equipped with active bracing components. The active exoskeleton is designed to be self-supportive and to be connected with a conventional load-bearing system for a multi-story building. This way, the gravitational load transfer is effectively decoupled from the active bracing that will be employed to resist lateral actions including wind and earthquakes. Connection detail solutions for minimal interference with slabs and other structural elements are evaluated. An integrated structural-control design strategy is formulated and tested through dynamic simulations of high-rise structures equipped with active exoskeletons under wind actions. A case study is carried out to evaluate potential material savings compared to conventional configurations for high-rise structures.