The Ozaki procedure [1] has the advantage of avoiding the implantation of foreign valve prosthesis in human heart, as it uses the patient's own pericardium to recreate the leaflets. Although this approach carries numerous benefits, it remains underutilized by surgeons. One potential explanation can be the lack of knowledge regarding the mechanical behavior of this new pericardial valve. It is worth noting that up to now there is no numerical study which examines the coupling dynamics between the blood flow and Ozaki leaflets. To address this issue, a Fluid-Structure interaction solver [2] is used based on a lattice Boltzmann solver (LBM) for the blood flow, coupled to a Finite element solver (FEM) for the valve, both approaches being linked by the Immersed boundary method (IBM). The simulations are performed on patient specific geometries for the leaflet and the aorta. A comparison between the native valve and the results after the Ozaki procedure will be presented by analyzing several performance criteria such as the dynamic and fluttering of the leaflets, the orifice area during systole, the blood flow patterns and also the wall shear stress. Our findings reveal similar physiological behavior, thereby confirming the potential of this alternative to bioprosthetic valves and its potential superiority in terms of biomechanical properties. E-mail: tom.fringand@univ-amu.fr REFERENCES [1] S. Ozaki, I. Kawase, H. Yamashita, S. Uchida, Y. Nozawa, T. Matsuyama, M. Takatoh, S. Hagiwara, Aortic valve reconstruction using self-developed aortic valve plasty system in aortic valve disease, Interactive cardiovascular and thoracic surgery 12 (4) (2011) 550–553. [2] I. Cheylan, T. Fringand, J. Jacob, J. Favier, Analysis of the immersed boundary method for turbulent fluid-structure interaction with lattice Boltzmann method, Journal of Computational Physics 492 (2023)