An optimum layout for two-dimensional honeycomb lattices with piezoelectric patches implanted into their cell walls is put forward in this research. The elastic characteristics are quantified at the lattice level integrating a bottom-up mechanics-based technique in conjunction with an RVE-based finite-element formulation. Higher voltage sensitivity of the entire lattice as compared to contemporary lattices [1-3] with regular piezoelectric patches is a distinct advantage of such optimal piezoelectric patch configuration. A wide range of lattice geometries, spanning auxetic and non-auxetic lattices with varying height ratios and piezo-thicknesses, have been studied in relation to the possibility of achieving real-time property tailoring in terms of its equivalent elastic constants. Such kind of flexibility in terms of customizing active properties in real-time gives us the freedom to tailor mechanical properties according to various working conditions and appliances which include morphing structures, wearable technology, soft robotics and many more.