Load alleviation as a technology can increase the fuel efficiency of an aircraft design by reducing the wing mass. Furthermore, the reduction of aerodynamic loads on the transonic, swept outer wing allows for higher aspect ratio wings. Load alleviation therefore is important for the aircraft design and should be considered within the conceptual design phase. Here, a design process is shown that integrates the relevant disciplines into the overall aircraft design through simplified but physics-based models. Surrogate model-based optimizations of the wing shape are done with respect to the fuel consumption. The design space contains nine geometrical wing shape parameters. The findings reveal that active load alleviation reduces the wing mass. The effect of load alleviation varies with the wing span. Optimization results show a fuel burn reduction potential of up to 11.6% compared to an optimized baseline design. The overall aircraft impact of load alleviation is also discussed in detail. This includes an exploration of the effects of simplified boundary conditions on the design. Moreover, the influence of various design parameters on the aircraft design, both with and without load alleviation, is assessed in depth based on neuronal network surrogate models.