Multiscale Modelling of Fluid Flow in a Lymph Node
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Lymph nodes (LNs) are organs scattered throughout the lymphatic system that play a vital role in our immune response by breaking down bacteria, viruses, and waste; the lymph is of fundamental importance in this process as it transports these substances inside the lymph node. The main mechanical features of the lymph node include the presence of a porous bulk region (lymphoid compartment, LC), surrounded by a thin layer (subcapsular sinus, SCS) where the fluid can flow freely. Lymph nodes are critical sites for the filtration and processing of lymph fluid, which contains a variety of immune cells, antigens, and other molecules. Understanding the fluid dynamics within lymph nodes is crucial for elucidating the mechanisms of immune response and for the development of therapies for lymphatic disorders. In this talk, we will describe a multiscale description of the fluid flow in a lymph node obtained using the asymptotic homogenization technique. Specifically, we will elucidate how this model empowers us to delineate the flow patterns, distribution of pressure, and shear stress within a lymph node.
