Region- and Rate-dependent Microscale Properties of Human Brain White Matter
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The brain is one of the most important and complex organs in the human body, with an extremely heterogeneous microstructure. Based on our recently proposed histology-informed model of the brain white matter, in this work we show an extension by considering region-specific microstructure while accounting for the variability in axonal orientation revealed by high-resolution imaging techniques. Rate dependence is modeled by including viscoelasticity at the microscopic level. The results obtained may improve our understanding of the biomechanics of the healthy human brain and offer insights into how mechanical properties may change in pathological conditions.
