Creating a detailed finite element model for aero-engines, encompassing all crucial components, is often a time-intensive process, especially when generating structured meshes for individual parts. To address this challenge, isogeometric analysis introduces an innovative technique that applies Computer-Aided Design (CAD) principles, specifically Non-uniform Rational B-splines (NURBS), to describe the geometry of the computational domain. This novel approach streamlines the transition from CAD models to the computational domain, significantly reducing the design-to-analysis time compared to traditional finite element analysis (FEA) methods. In this study, we demonstrate a NURBS-based model generation process using an in-house tool. This process involves creating a simplified aero-engine model, utilized for transient implicit computations simulating rotor acceleration. The results of LS Dyna simulations on the simplified aero-engine model, along with findings related to material simulations, are presented. These material simulation outcomes are then compared with classical finite element models and experimental data, providing valuable insights into the efficacy of the NURBS-based approach.