Articular cartilage exhibits a complex mechanical behavior essential for joint functionality. This study presents a computational framework aimed at understanding and simulating the mechanical response of articular cartilage under various loading conditions. The proposed model employs a biphasic approach, considering the cartilage as a porous medium comprising a solid, fiber-reinforced phase and a fluid phase introducing an osmotic pressure [1,2]. The model parameters were calibrated by integrating experimental data from tensile and confined compression tests to accurately capture the material behavior across different loading regimes. Before employing computational models in researching cartilage diseases, it is essential to validate the modeling approach's ability to produce accurate predictions. Furthermore, it is crucial to quantify the sensitivity of these predictions to variations in model inputs. To this end, a sensitivity analysis was conducted to assess the influence of model parameters on the predicted mechanical behavior. This analysis not only identified key parameters significantly impacting the model outcomes but also enhanced the understanding of the underlying mechanisms governing articular cartilage behavior. The computational model's effectiveness in simulating the intricate mechanical response of articular cartilage under diverse loading scenarios offers a valuable tool for predicting its behavior in physiological conditions and pathological states. The integration of experimental data and sensitivity analyses enhances the model's reliability and applicability in elucidating the mechanics of articular cartilage, contributing to advancements in musculoskeletal biomechanics and clinical interventions. [1] D.M. Pierce, T. Ricken and G.A. Holzapfel, A hyperelastic biphasic fibre-reinforced model of articular cartilage considering distributed collagen fibre orientations. Comput Methods Biomech Biomed Engin, Vol. 16, pp. 1344--1361, 2012. [2] F.S. Egli, T. Ricken and D.M. Pierce, A hyperelastic biphasic fiber reinforced model of articular cartilage incorporating the influences of osmotic pressure and damage. Advances in Engineering Materials, Structures and Systems, pp. 308--561, 2019.