In this work, numerical simulations are conducted using the recently developed generalized wall-modeled large eddy simulation (GWMLES) model of the authors. It consists of an extended formulation of the classical WMLES approach, which also enables the modeling of the entire log-layer by using a Reynolds-Averaged Navier Stokes (RANS) model \cite{AMATRIAIN2023}. It provides a level of accuracy similar to recent LES results, as well as computational cost savings that are proportional to the Reynolds number in wall bounded flows. Considering standard benchmark cases with features of industrial flows, GWMLES has been shown to reduce the drawbacks of current methodologies based on near-wall modeled turbulence \cite{SPALART2006,BOSE2018}, representing a significant advancement in the simulation of wall-bounded flows at high Reynolds numbers. The current contribution reviews the main features and outcomes of the newly developed GWMLES, and showcases its power with a complex industrial case that is representative of an aeronautical flow. The comparison uses extensive LES and experimental data as references, with a particular focus on spectral analysis.